Polyphosphoinositides and PA

 - are minor lipid constituents

- exhibit rapid turnover Ideal and typical for signalling! lipidology

 o Phospholipase C

o Phospholipase D

o Phospholipase A2

o Phosphoinositide 3-kinase Phospholipase C

 

seRecBCD

enzyme is a heterotrimeric helicase/nuclease quence into the species active in homologous recombithat

initiates homologous recombination at double- nation: ssDNA terminated at . and coated with RecA

stranded DNA breaks. Several of its activities are regu- protein (Anderson and Kowalczykowski, 1997b; Dixon

convergence for many NF?B activation pathways, Activation of NF?B can be stimuli by TNF-?, Lipopolysaccharide /bacterial endotoxine (LPS), double stranded RNA (viral infection) , IL-1, proinflammatory such as cytokines. After stimulation by many known stimuli, the NEMO is the subunit absolutely necessary for the activation of the IKK complex. Once the IKK complex is formed then the inhibitor kB protein (IkB) is phosphorylated by the IkB kinase (IKK) complex and promptly degraded by the ubiquitin-26S proteasome pathway and finally the NF?B is activated. Now the NF?B can be shuttle to the nucleus where it activates target-gene transcription. (figure 2)